A 58-year-old man receives intravenous alteplase treatment for acute stroke. Five minutes following completion of alteplase infusion, he develops orolingual angioedema. Which of the following drugs may have increased the risk of developing orolingual angioedema in this patient?

  • A. ACE inhibitor.
  • B. GP IIb/IIIa receptor antagonist.
  • C. Phosphodiesterase inhibitor.
  • D. Thiazide diuretic.