Presentation - 3Ps - Polyuria, Polydipsia, Polyphagia. Non-specific symptoms: weakness, vomiting, abdominal pain, blurry vision. Physical Exam: Acetone smell; Dehydration / tachycardia / hypotension / shock; Kussmaul's respiration (deep/labored breathing secondary to acidosis)
Thyroid overactivity in Graves’ disease results from formation of IgG antibodies that bind to and activate TSH receptors. Consequently, there is overproduction of hormone with cessation of TSH secretion. Graves’…
When glucocorticoid medication is suddenly withheld, the atrophic cortex is unable to produce sufficient cortisol and a potentially life-threatening cortisol deficiency may develop. Therefore, glucocorticoid therapy should always be tapered off by gradual reduction of the dosage.
Thyroid storm is an extreme version of hyperthyroidism with a mortality rate that approaches 30%, even with treatment. The recognition and management of thyroid storm can be difficult in the…
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