Anticoagulants and Fibrinolytics

Structurally related to vitamin K, 4-hydroxycoumarins act as “false” vitamin K and prevent regeneration of reduced (active) vitamin K from vitamin K epoxide, hence the synthesis of vitamin K-dependent clotting factors. Coumarins are well absorbed after oral administration. Their duration of action varies considerably. Synthesis of clotting factors depends on the intrahepatocytic concentration ratio of coumarins to vitamin K.

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Threatening Hemorrhage in the Patient Taking an Oral Anticoagulant Medication

Threatening Hemorrhage in the Patient Taking an Oral Anticoagulant Medication
Guidelines for the Management of Supratherapeutic INR

Oral anticoagulant medications are commonly prescribed. Whether it is a traditional vitamin K antagonist (VKA) or a novel oral anticoagulant (NOAC) medication, all carry the risk of serious hemorrhage. Traditional…

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Reversal of Anticoagulant Therapy

In the setting of life-threatening hemorrhage, the standard ABCs may be reconsidered as A2BC, with the additional “A” representing concomitant anticoagulant reversal. The anticoagulated patient with life-threatening hemorrhage does not…

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Tumor Lysis Syndrome (TLS)

Tumor Lysis Syndrome (TLS)
Treatment of Metabolic Abnormalities of Tumor Lysis Syndrome

What is Tumor Lysis Syndrome Tumor lysis syndrome (TLS) is a metabolic syndrome characterized by renal failure and multiple metabolic abnormalities caused by the rapid and massive cell destruction and…

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