Correct answer = Simvastatin.
Simvastatin, an HMG CoA reductase inhibitor (statin), is the most effective option for lowering LDL cholesterol, achieving reductions of 30% to 41% from baseline levels.
Fenofibrate and niacin are more effective at lowering triglyceride levels or raising HDL levels (niacin).
Colesevelam can reduce LDL levels but not as effectively as statins.
Ezetimibe lowers LDL levels modestly compared to the LDL reduction achieved by statins