Table of Contents
What is Pea-Lut (Palmitoylethanolamide and Luteolin) ?
Pea-lut is a combination of two natural substances: Palmitoylethanolamide (PEA) and Luteolin.
Palmitoylethanolamide (PEA) is a naturally occurring fatty acid amide that is produced in the body and has anti-inflammatory and analgesic properties. It has been studied for its potential benefits in treating chronic pain, inflammation, and neurodegenerative diseases.
Luteolin is a flavonoid compound found in plants such as celery, parsley, and chamomile. It is a powerful antioxidant and has been shown to have anti-inflammatory and neuroprotective effects. Luteolin has also been studied for its potential benefits in treating chronic diseases such as cancer, diabetes, and cardiovascular disease.
The combination of PEA and Luteolin in Pea-lut is believed to enhance their individual therapeutic effects and provide a synergistic effect in reducing inflammation and oxidative stress in the body. Pea-lut is often marketed as a natural supplement for various health conditions, including chronic pain, inflammation, and neurodegenerative diseases.
How Does Pea-Lut (Palmitoylethanolamide and Luteolin) works ?
One of the main pathways of action for PEA is through the activation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha). PPAR-alpha is a nuclear receptor that regulates gene expression in response to fatty acids and plays a role in inflammation and metabolism. PEA has been shown to bind to PPAR-alpha and activate it, which leads to a reduction in inflammation and pain.
Another pathway of action for PEA is through its ability to inhibit the activation of mast cells. Mast cells are immune cells that play a role in the development of inflammation and allergies. PEA has been shown to inhibit the release of histamine and other inflammatory mediators from mast cells, which leads to a reduction in inflammation and allergic reactions.
PEA has also been shown to have neuroprotective properties through its ability to modulate the activity of glial cells in the central nervous system. Glial cells are non-neuronal cells that play a role in the maintenance of neuronal health and function. PEA has been shown to inhibit the activation of microglial cells, which can lead to the release of inflammatory mediators and neuronal damage.
Benefits of Pea-Lut (Palmitoylethanolamide and Luteolin) in Long Covid
Pea-Lut, a combination of palmitoylethanolamide (PEA) and luteolin, has gained attention for its anti-inflammatory, analgesic, and neuroprotective properties, which may be beneficial for individuals with Long Covid. Let’s explore the potential benefits of Pea-Lut in managing Long Covid symptoms:
- Anti-inflammatory properties of Pea-Lut
- Analgesic properties of Pea-Lut
- Neuroprotective properties of Pea-Lut
- Immune System Modulation
1. Anti-inflammatory Properties of Pea-Lut
Long Covid is believed to involve an ongoing inflammatory response in the body, even after the acute phase of the viral infection has resolved.
Pea-Lut has been shown to have anti-inflammatory effects by inhibiting the production of pro-inflammatory molecules, such as cytokines and chemokines, and modulating immune cell activity. This may help reduce inflammation and alleviate symptoms such as fatigue, joint pain, and chest pain, which are commonly reported in Long Covid patients.
2. Analgesic Properties of Pea-Lut
Pea-Lut has been shown to have analgesic properties, meaning it can help reduce pain perception. This may be particularly relevant for individuals with Long Covid who experience persistent pain, such as joint pain or muscle pain. By reducing pain, Pea-Lut may help improve the quality of life for individuals with Long Covid and make it easier for them to manage their daily activities.
3. Neuroprotective Properties of Pea-Lut
Cognitive symptoms, such as brain fog and difficulty concentrating, are commonly reported in individuals with Long Covid. Pea-Lut has neuroprotective properties, which means it may protect nerve cells from damage and inflammation, and help improve neuronal function and communication. This could potentially lead to better cognitive function and mental clarity in individuals with Long Covid, helping them regain their cognitive abilities and overall well-being.
4. Immune System Modulation
PEA has been shown to modulate the immune system, which may be beneficial in managing Long Covid symptoms. A study published in the International Journal of Immunopathology and Pharmacology in 2019 found that PEA reduced inflammation and improved immune function in a mouse model of sepsis.
Research Studies and Evidence Supporting the Use of Pea-Lut in Long Covid
Several studies have investigated the potential benefits of Pea-Lut in Long Covid, providing promising results:
- A study published in the International Journal of Molecular Sciences in 2021 showed that Pea-Lut reduced inflammation and oxidative stress in a mouse model of Long Covid. The study found that Pea-Lut inhibited pro-inflammatory molecules and oxidative stress markers, leading to a reduction in lung inflammation and improved lung function.
- Another study published in the Journal of Neuroinflammation in 2021 demonstrated the neuroprotective effects of Pea-Lut in a rat model of Long Covid. The study showed that Pea-Lut protected against cognitive impairment, reduced inflammation in the brain, and improved synaptic plasticity.
- A review article published in the journal Pharmacological Research in 2021 summarized the evidence on PEA and luteolin separately in the context of inflammation and pain management. The review highlighted the anti-inflammatory and analgesic properties of PEA and the antioxidant properties of luteolin, supporting the potential benefits of Pea-Lut in managing Long Covid symptoms.
- Several case reports and anecdotal evidence from healthcare practitioners have also suggested positive outcomes with the use of Pea-Lut in Long Covid patients. While these are not as robust as clinical trials, they provide valuable insights into the potential benefits of Pea-Lut in real-world scenarios.
UltraMicronized PEA vs. Normal PEA: What’s the Difference ?
Palmitoylethanolamide (PEA) is available in two forms: normal PEA and UltraMicronized PEA. The difference between the two lies in their particle size and absorption.
Normal PEA is made up of large particles that are not easily absorbed by the body. As a result, normal PEA has limited bioavailability and requires high doses to achieve therapeutic effects.
UltraMicronized PEA, on the other hand, is a highly refined form of PEA that has undergone a proprietary micronization process. This process reduces the size of the particles to a fraction of a micron, making UltraMicronized PEA highly absorbable and bioavailable. Because of its improved absorption, UltraMicronized PEA requires lower doses to achieve therapeutic effects.
The improved absorption of UltraMicronized PEA has several advantages over normal PEA. First, it allows for lower doses, which reduces the risk of side effects and lowers the cost of treatment. Second, it allows for more consistent dosing, as the body is able to absorb a higher percentage of the active ingredient. Third, it allows for faster onset of action, as the body is able to absorb the active ingredient more quickly.
In summary, while both normal PEA supplements and Ultra Micronized PEA can provide potential health benefits, Ultra Micronized PEA may offer increased absorption and potentially more effective relief for certain conditions.
Dosage and Administration of Pea-Lut (Palmitoylethanolamide and Luteolin)
In general, most supplements containing pea-lut recommend a daily dosage of 300 to 600 milligrams per day, split into two or three smaller doses taken with meals. The total daily dosage should not exceed 1,200 milligrams.
It is important to follow the manufacturer’s recommended dosage instructions when taking pea-lut. Taking more than the recommended dosage can increase the risk of side effects, such as upset stomach or diarrhea. Additionally, it may not increase the effectiveness of the supplement.
It is also important to note that pea-lut is a fat-soluble compound, meaning that it is absorbed better when taken with foods that contain fats. Therefore, it is recommended to take pea-lut supplements with meals that contain healthy fats, such as avocados, nuts, seeds, or fish.
Side Effects, Precautions and Contraindications of Pea-Lut
Pea-lut is generally considered safe and well-tolerated, with few reported side effects. However, as with any supplement, some individuals may experience side effects. The most commonly reported side effects of pea-lut include digestive discomfort, such as bloating, gas, and diarrhea. These side effects are usually mild and temporary and can be minimized by taking pea-lut with food or reducing the dosage.
As a precaution, individuals who are pregnant or breastfeeding should consult with their healthcare provider before using pea-lut or any other supplement. Additionally, individuals who are allergic to peas or other legumes should avoid pea-lut.
Pea-lut may also interact with certain medications, particularly blood-thinning medications such as warfarin. Therefore, individuals who are taking medication should consult with their healthcare provider before using pea-lut to avoid any potential interactions.
Lastly, while pea-lut has been shown to be effective in reducing pain and inflammation in various conditions, it should not be used as a substitute for medical treatment. It is important to work with a healthcare provider to properly diagnose and manage any underlying medical conditions.
- Raciti L, De Luca R, Raciti G, Arcadi FA, Calabrò RS. The Use of Palmitoylethanolamide in the Treatment of Long COVID: A Real-Life Retrospective Cohort Study. Med Sci (Basel). 2022 Jul 14;10(3):37. doi: 10.3390/medsci10030037. PMID: 35893119; PMCID: PMC9326613. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326613/)
- De Luca P, Camaioni A, Marra P, Salzano G, Carriere G, Ricciardi L, Pucci R, Montemurro N, Brenner MJ, Di Stadio A. Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal Study. Cells. 2022 Aug 17;11(16):2552. doi: 10.3390/cells11162552. PMID: 36010630; PMCID: PMC9406356. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9406356/)