Antibiotics – Inhibitors of Tetrahydrofolate Synthesis

Antibiotics – Inhibitors of Tetrahydrofolate Synthesis
Antibiotics - Inhibitors of tetrahydrofolate synthesis

Most bacteria do not have a requirement for folate, because they are capable of synthesizing folate, more precisely dihydrofolate DHF, from precursors. Selective interference with bacterial synthesis of Tetrahydrofolate (THF) can be achieved with sulfonamides and trimethoprim.

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Measures and Regimens for Preventing Drug-Induced Cushing’s Syndrome

Measures and Regimens for Preventing Drug-Induced Cushing’s Syndrome
Cortisol release and its modification by glucocorticoids

When glucocorticoid medication is suddenly withheld, the atrophic cortex is unable to produce sufficient cortisol and a potentially life-threatening cortisol deficiency may develop. Therefore, glucocorticoid therapy should always be tapered off by gradual reduction of the dosage.

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Glucocorticoid Therapy – Principal and Adverse Effects

Glucocorticoid Therapy – Principal and Adverse Effects
Glucocorticoids - principal and adverse effects

I. Replacement therapy The adrenal cortex (AC) produces the glucocorticoid cortisol (hydrocortisone) and the mineralocorticoid aldosterone. Both steroid hormones are vitally important in adaptation responses to stress situations, such as…

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