Antibiotics – Inhibitors of Tetrahydrofolate Synthesis

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Antibiotics - Inhibitors of tetrahydrofolate synthesis

Most bacteria do not have a requirement for folate, because they are capable of synthesizing folate, more precisely dihydrofolate DHF, from precursors. Selective interference with bacterial synthesis of Tetrahydrofolate (THF) can be achieved with sulfonamides and trimethoprim.

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Headache Algorithm

  • Post category:Neurology

Emergency department evaluation relies on excluding life-threatening causes of Headache (killers), specifically SAH and meningitis. Then consider other serious causes of headache that can debilitate the patient (the maimers). When these have been excluded, we can then diagnose primary headache syndromes.

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